Could a vitamin deficiency cause 'double jointedness' and hypermobile Ehlers Danlos syndrome? Frontiers Mechanobiology in the Comorbidities of Ehlers Danlos Syndrome Ehlers Danlos syndrome MEpedia What is Dermatosparaxis Ehlers Danlos Syndrome (dEDS)? Dermatosparaxis Ehlers Danlos syndrome is an ultra rare heritable connective tissue disorder that causes severe skin fragility, excess skin, severe bruising, and characteristic facial features ADHD. Depression. MCAS. POTS. Ehlers Danlos Hypermobility. Histamine intolerance. Chronic fatigue. [Name your thing here] that moves around and comes back and maybe has a new name every few years depending on Ehlers Danlos syndrome (EDS) is a group of 13 related genetic (heritable) connective tissue disorders. EDS, particularly the hypermobile type (hEDS), frequently overlaps with Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation