Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most 5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Glutathione or L Glutathione: What is Better for Skin? Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Not feeling well? *Don't* reach for Tylenol! Here are 8 reasons why. Some experts maintain that if acetaminophen were a brand new drug up for approval today, it would *not* get approved at Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: